BSORF Gene Entry : BG11190
ORF ID
BG11190 (
BSU17680
)
Location
1902219..1903058
Length
279 aa
840 bp
+upstream
bp +downstream
bp
Molecular mass
32654.8
Isoelectric point
5.5
Gene
thyA
Subtilist
thyA
UniProt
P42326
Product
thymidylate synthase A
EC number
2.1.1.45
Motif
pf:Thymidylat_synt 3 279
ps:THYMIDYLATE_SYNTHASE 141
ps:THYMIDYLATE_SYNTHASE 142
Ortholog
SSDB
Paralog
SSDB
Homology
FASTA-sp   BLAST-nr
3D Structure
PDB
Category
2.3 : Metabolism of nucleotides and nucleic acids  
KEGG pathway
Pyrimidine metabolism
One carbon pool by folate
Essential
No (Reference)
Mutant
Northern
no
BSTF
DNA array data
BG11190
Reference
1.
Tam NH, Borriss R (1995) The thyA gene from Bacillus subtilis exhibits similarity with the phage phi 3T thymidylate synthase gene. Microbiology 141 ( Pt 2):291-7.[PMID:
7704257
]
2.
Tam NH, Borriss R (1998) Genes encoding thymidylate synthases A and B in the genus Bacillus are members of two distinct families. Mol Gen Genet 258:427-30.[PMID:
9648749
]
3.
Stout TJ, Schellenberger U, Santi DV, Stroud RM (1998) Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis. Biochemistry 37:14736-47.[PMID:
9778348
]
4.
Fox KM, Maley F, Garibian A, Changchien LM, Van Roey P (1999) Crystal structure of thymidylate synthase A from Bacillus subtilis. Protein Sci 8:538-44.[PMID:
10091656
]
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