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BSORF Gene Entry : BG11190

ORF IDBG11190 (BSU17680)
Location1902219..1903058  
Length279 aa
840 bp   +upstreambp   +downstreambp
Molecular mass32654.8
Isoelectric point5.5
GenethyA         Subtilist      thyA         UniProt      P42326
Productthymidylate synthase A
EC number2.1.1.45
Motifpf:Thymidylat_synt 3 279
ps:THYMIDYLATE_SYNTHASE 141
ps:THYMIDYLATE_SYNTHASE 142
LocalizationPSORT  SOSUI
Ortholog SSDB     COG
Paralog SSDB
Homology FASTA-sp   BLAST-nr
3D Structure PDB     GTOP
Category2.3 : Metabolism of nucleotides and nucleic acids  
KEGG pathway 
Pyrimidine metabolism

One carbon pool by folate

EssentialNo (Reference)
Mutant
Northernno
BSTF
DNA array data BG11190
Reference
1. Tam NH, Borriss R (1995) The thyA gene from Bacillus subtilis exhibits similarity with the phage phi 3T thymidylate synthase gene. Microbiology 141 ( Pt 2):291-7.[PMID:7704257]
2. Tam NH, Borriss R (1998) Genes encoding thymidylate synthases A and B in the genus Bacillus are members of two distinct families. Mol Gen Genet 258:427-30.[PMID:9648749]
3. Stout TJ, Schellenberger U, Santi DV, Stroud RM (1998) Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis. Biochemistry 37:14736-47.[PMID:9778348]
4. Fox KM, Maley F, Garibian A, Changchien LM, Van Roey P (1999) Crystal structure of thymidylate synthase A from Bacillus subtilis. Protein Sci 8:538-44.[PMID:10091656]
PubMed search

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