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BSORF Gene Entry : BG10114

ORF IDBG10114 (BSU00510)
Location57745..58698  
Length317 aa
954 bp   +upstreambp   +downstreambp
Molecular mass34714.1
Isoelectric point5.89
Geneprs         Subtilist      prs         UniProt      P14193
Productphosphoribosyl pyrophosphate synthetase
EC number2.7.6.1
Motifpf:Pribosyltran 149 254
ps:PRPP_SYNTHETASE 134
ps:PUR_PYR_PR_TRANSFER 220
LocalizationPSORT  SOSUI
Ortholog SSDB     COG
Paralog SSDB
Homology FASTA-sp   BLAST-nr
3D Structure PDB     GTOP
Category2.3 : Metabolism of nucleotides and nucleic acids  
KEGG pathway 
Pentose phosphate pathway

Purine metabolism

EssentialYes (Mutant)
MutantPRSp
Northernyes
BSTF
DNA array data BG10114
Reference
1. Nilsson D, Hove-Jensen B (1987) Phosphoribosylpyrophosphate synthetase of Bacillus subtilis. Cloning, characterization and chromosomal mapping of the prs gene. Gene 53:247-55.[PMID:3038693]
2. Muchmore CR, Krahn JM, Kim JH, Zalkin H, Smith JL (1998) Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli. Protein Sci 7:39-51.[PMID:9514258]
3. Eriksen TA, Kadziola A, Bentsen AK, Harlow KW, Larsen S (2000) Structural basis for the function of Bacillus subtilis phosphoribosyl-pyrophosphate synthetase. Nat Struct Biol 7:303-8.[PMID:10742175]
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