BSTF Data for BG10699


ORF IDBG10699
SynonymdegR,prtR
ClassHTH
Familyunique
Family description
Mutant/Isogenic strain
Sensor
Target genesaprE, nprE (positeve regulation on high copy plasmid)(1,4)
cis Sequencenot
Ligandnot
CommentThe positive effect of DegR on the production of the extracellular proteases is brought about by the stabilization of DegU-phosphate, which in turn may result in the stimulation of transcription of the exoprotease genes (2). ComK negatively regulates degR expression by preventing sigmaD-driven transcription of degR, possibly through interaction with the control region (3).
Reference
1. Tanaka T, Kawata M, Nagami Y, Uchiyama H (1987) prtR enhances the mRNA level of the Bacillus subtilis extracellular proteases. J Bacteriol 169:3044-50. [PMID:3110132]
2. Mukai K, Kawata-Mukai M, Tanaka T (1992) Stabilization of phosphorylated Bacillus subtilis DegU by DegR. J Bacteriol 174:7954-62. [PMID:1459944]
3. Ogura M, Tanaka T (1997) Bacillus subtilis ComK negatively regulates degR gene expression. Mol Gen Genet 254:157-65. [PMID:9108277]
4. Yang M, Shimotsu H, Ferrari E, Henner DJ (1987) Characterization and mapping of the Bacillus subtilis prtR gene. J Bacteriol 169:434-7. [PMID:3098734]
PubMed search
Ortholog SSDB     COG
Paralog SSDB
Motif SSDB
Localization PSORT   SOSUI