BSTF Data for BG10666


ORF IDBG10666
SynonymhutP,hutP1
ClassRNA binding regulator
Familyunique
Family description
Mutant/Isogenic strainHUTPN1(2)
Sensor
Target geneshutPHUIGM(1)
cis SequenceRAT (1,2)
Ligandhistidine in medium (1) and in cell (2).
CommentIn the presence of histidine and Mg2+, purified HutP binds hut RNA bearing RAT (2). Crystallization of HutP (3).
Reference
1. Wray LV Jr, Fisher SH (1994) Analysis of Bacillus subtilis hut operon expression indicates that histidine-dependent induction is mediated primarily by transcriptional antitermination and that amino acid repression is mediated by two mechanisms: regulation of transcription initiation and inhibition of histidine transport. J Bacteriol 176:5466-73. [PMID:8071225]
2. Oda M, Kobayashi N, Ito A, Kurusu Y, Taira K (2000) cis-acting regulatory sequences for antitermination in the transcript of the Bacillus subtilis hut operon and histidine-dependent binding of HutP to the transcript containing the regulatory sequences. Mol Microbiol 35:1244-54. [PMID:10712704]
3. Kumarevel TS, Fujimoto Z, Padmanabhan B, Oda M, Nishikawa S, Mizuno H, Kumar PK (2002) Crystallization and preliminary X-ray diffraction studies of HutP protein: an RNA-binding protein that regulates the transcription of hut operon in Bacillus subtilis. J Struct Biol 138:237-40. [PMID:12217662]
PubMed search
Ortholog SSDB     COG
Paralog SSDB
Motif SSDB
Localization PSORT   SOSUI