BSTF Data for BG10474

ClassRNA binding regulator
Family descriptionBglG antiterminator motif
Mutant/Isogenic strainBGW4/168 (2)
Target genesbglPH(1), licS(2)
cis SequenceRAT (1,2)
Ligandsalicin(1), lichenan, terasaccharide (2) in medium.
CommentCatabolite repression of bglPH iw mediated two distinct pathway, one of which invoolves licT(3). LicT becomes phosphorylated in the presence of PEP, enzyme I and HPr, which is related to LicT-mediated CcpA-independent carbon catabolite repression (4). Crystal structure of an activated form of the PTS regulation domain (5). Sites of positive and negative regulation in LicT(6). Dimer stabilization upon LicT activation (7).
1. Kruger S, Hecker M (1995) Regulation of the putative bglPH operon for aryl-beta-glucoside utilization in Bacillus subtilis. J Bacteriol 177:5590-7. [PMID:7559347]
2. Schnetz K, Stulke J, Gertz S, Kruger S, Krieg M, Hecker M, Rak B (1996) LicT, a Bacillus subtilis transcriptional antiterminator protein of the BglG family. J Bacteriol 178:1971-9. [PMID:8606172]
3. Kruger S, Gertz S, Hecker M (1996) Transcriptional analysis of bglPH expression in Bacillus subtilis: evidence for two distinct pathways mediating carbon catabolite repression. J Bacteriol 178:2637-44. [PMID:8626332]
4. Lindner C, Galinier A, Hecker M, Deutscher J (1999) Regulation of the activity of the Bacillus subtilis antiterminator LicT by multiple PEP-dependent, enzyme I- and HPr-catalysed phosphorylation. Mol Microbiol 31:995-1006. [PMID:10048041]
5. van Tilbeurgh H, Le Coq D, Declerck N (2001) Crystal structure of an activated form of the PTS regulation domain from the LicT transcriptional antiterminator. EMBO J 20:3789-99. [PMID:11447120]
6. Tortosa P, Declerck N, Dutartre H, Lindner C, Deutscher J, Le Coq D (2001) Sites of positive and negative regulation in the Bacillus subtilis antiterminators LicT and SacY. Mol Microbiol 41:1381-93. [PMID:11580842]
7. Declerck N, Dutartre H, Receveur V, Dubois V, Royer C, Aymerich S, van Tilbeurgh H (2001) Dimer stabilization upon activation of the transcriptional antiterminator LicT. J Mol Biol 314:671-81. [PMID:11733988]
8. Lindner C, Hecker M, Le Coq D, Deutscher J (2002) Bacillus subtilis mutant LicT antiterminators exhibiting enzyme I- and HPr-independent antitermination affect catabolite repression of the bglPH operon. J Bacteriol 184:4819-28. [PMID:12169607]
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Ortholog SSDB     COG
Paralog SSDB
Motif SSDB
Localization PSORT   SOSUI