BSTF Data for BG10411

Classtwo comp regulator
Family description
Mutant/Isogenic strainmany Ala-substituted mutants/JH642(1), UOT-0779(spo0F221)/UOT-1035(2), JH12578(3)
SensorKinA,B,C(4), KinD,E(9)
Target genesnot
cis Sequencenot
CommentSpo0F lacks DNA binding domein and is involved in sporultion phosphorelay (10,11). Spo0F inhibits the ability of KinC to donate phosphate to spo0A (9). The spatial arrangement of the beta4-alpha4 loop may play a critical role in kinase selection by Spo0F (6).Processing of the Phr precursor proteins into the active pentapeptide form is a key event in the initiation of sporulation (7). Structure of SpoOF (8).
1. Tzeng YL, Hoch JA (1997) Molecular recognition in signal transduction: the interaction surfaces of the Spo0F response regulator with its cognate phosphorelay proteins revealed by alanine scanning mutagenesis. J Mol Biol 272:200-12. [PMID:9299348]
2. Yoshikawa H, Kazami J, Yamashita S, Chibazakura T, Sone H, Kawamura F, Oda M, Isaka M, Kobayashi Y, Saito H (1986) Revised assignment for the Bacillus subtilis spo0F gene and its homology with spo0A and with two Escherichia coli genes. Nucleic Acids Res 14:1063-72. [PMID:3003689]
3. Perego M, Hoch JA (1991) Negative regulation of Bacillus subtilis sporulation by the spo0E gene product. J Bacteriol 173:2514-20. [PMID:1901567]
4. LeDeaux JR, Grossman AD (1995) Isolation and characterization of kinC, a gene that encodes a sensor kinase homologous to the sporulation sensor kinases KinA and KinB in Bacillus subtilis. J Bacteriol 177:166-75. [PMID:8002614]
5. Ishikawa S, Core L, Perego M (2002) Biochemical characterization of aspartyl phosphate phosphatase interaction with a phosphorylated response regulator and its inhibition by a pentapeptide. J Biol Chem 277:20483-9. [PMID:11923303]
6. Jiang M, Tzeng YL, Feher VA, Perego M, Hoch JA (1999) Alanine mutants of the Spo0F response regulator modifying specificity for sensor kinases in sporulation initiation. Mol Microbiol 33:389-95. [PMID:10411754]
7. Stephenson S, Mueller C, Jiang M, Perego M (2003) Molecular analysis of Phr peptide processing in Bacillus subtilis. J Bacteriol 185:4861-71. [PMID:12897006]
8. Madhusudan, Zapf J, Whiteley JM, Hoch JA, Xuong NH, Varughese KI (1996) Crystal structure of a phosphatase-resistant mutant of sporulation response regulator Spo0F from Bacillus subtilis. Structure 4:679-90. [PMID:8805550]
9. Jiang M, Shao W, Perego M, Hoch JA (2000) Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis. Mol Microbiol 38:535-42. [PMID:11069677]
10. Hoch J (1993) spo0 genes, the phosphorelay, and the initiation of sporlation, p.747-755. In Sonenshein AL, Hoch, JA, Losick, R (ed), Bacillus subtilis and its related bacteria, American Sciety for Microbiology, Washington, DC. [PMID:A0002]
11. Perego M, Hoch JA (2002) Two component systems, phosphorelays, and regulation of their activities by phosphatases, p.473-481.In Sonenshein AL, Hoch JA Losick R, Bacillus subtilis and its closest relatives, American Society for Microbiology, Washington, DC. [PMID:A0004]
PubMed search
Ortholog SSDB     COG
Paralog SSDB
Motif SSDB
Localization PSORT   SOSUI