BSTF Data for BG10381


ORF IDBG10381
SynonymcomA,srfB,comAA
Classtwo comp regulator
FamilyluxR
Family description
Mutant/Isogenic straincomA124::Tn917lac/BD630(1)
SensorComP
Target genesdegQ(2), rapA-phrA(3), srfA(4, 5), rapC-phrC(6), rapE(7),rapF(12).
cis SequenceTTGCGGN4CCGCAA(4, 5)
LigandThe pheromone ComX contacts ComP directly (9).
CommentGamma-PGA synthesis in B. subtilis (natto) is under the control of ComPA (8). srfA activation seen in the comP mutant is dependent on the expression of pta (10). ComA was essential for bacilysin biosynthesis (11). Dna micrarray analysis (12). ComX variants are isoprenylated by the post-translational modification (13). comA is involved in the regulation of post-exponential phase prokaryotic differentiation (14). PhrC (ERGMT) peptide inhibits RapC acting on ComA (15). Spx disrupts complex formation between ComA and promoter-bound RNAP (16).Interaction of RapC with ComA inhibits response regulator-DNA binding
Reference
1. Hahn J, Albano M, Dubnau D (1987) Isolation and characterization of Tn917lac-generated competence mutants of Bacillus subtilis. J Bacteriol 169:3104-9. [PMID:3036770]
2. Msadek T, Kunst F, Klier A, Rapoport G (1991) DegS-DegU and ComP-ComA modulator-effector pairs control expression of the Bacillus subtilis pleiotropic regulatory gene degQ. J Bacteriol 173:2366-77. [PMID:1901055]
3. Mueller JP, Bukusoglu G, Sonenshein AL (1992) Transcriptional regulation of Bacillus subtilis glucose starvation-inducible genes: control of gsiA by the ComP-ComA signal transduction system. J Bacteriol 174:4361-73. [PMID:1378051]
4. Nakano MM, Zuber P (1993) Mutational analysis of the regulatory region of the srfA operon in Bacillus subtilis. J Bacteriol 175:3188-91. [PMID:8491732]
5. Roggiani M, Dubnau D (1993) ComA, a phosphorylated response regulator protein of Bacillus subtilis, binds to the promoter region of srfA. J Bacteriol 175:3182-7. [PMID:8387999]
6. Lazazzera BA, Kurtser IG, McQuade RS, Grossman AD (1999) An autoregulatory circuit affecting peptide signaling in Bacillus subtilis. J Bacteriol 181:5193-200. [PMID:10464187]
7. Jiang M, Grau R, Perego M (2000) Differential processing of propeptide inhibitors of Rap phosphatases in Bacillus subtilis. J Bacteriol 182:303-10. [PMID:10629174]
8. Tran LS, Nagai T, Itoh Y (2000) Divergent structure of the ComQXPA quorum-sensing components: molecular basis of strain-specific communication mechanism in Bacillus subtilis. Mol Microbiol 37:1159-71. [PMID:10972833]
9. Tortosa P, Logsdon L, Kraigher B, Itoh Y, Mandic-Mulec I, Dubnau D (2001) Specificity and genetic polymorphism of the Bacillus competence quorum-sensing system. J Bacteriol 183:451-60. [PMID:11133937]
10. Kim SB, Shin BS, Choi SK, Kim CK, Park SH (2001) Involvement of acetyl phosphate in the in vivo activation of the response regulator ComA in Bacillus subtilis. FEMS Microbiol Lett 195:179-83. [PMID:11179649]
11. Yazgan A, Ozcengiz G, Marahiel MA (2001) Tn10 insertional mutations of Bacillus subtilis that block the biosynthesis of bacilysin. Biochim Biophys Acta 1518:87-94. [PMID:11267663]
12. Ogura M, Yamaguchi H, Yoshida Ki, Fujita Y, Tanaka T (2001) DNA microarray analysis of Bacillus subtilis DegU, ComA and PhoP regulons: an approach to comprehensive analysis of B.subtilis two-component regulatory systems. Nucleic Acids Res 29:3804-13. [PMID:11557812]
13. Ansaldi M, Marolt D, Stebe T, Mandic-Mulec I, Dubnau D (2002) Specific activation of the Bacillus quorum-sensing systems by isoprenylated pheromone variants. Mol Microbiol 44:1561-73. [PMID:12067344]
14. Sung HM, Yasbin RE (2002) Adaptive, or stationary-phase, mutagenesis, a component of bacterial differentiation in Bacillus subtilis. J Bacteriol 184:5641-53. [PMID:12270822]
15. Stephenson S, Mueller C, Jiang M, Perego M (2003) Molecular analysis of Phr peptide processing in Bacillus subtilis. J Bacteriol 185:4861-71. [PMID:12897006]
16. Nakano S, Nakano MM, Zhang Y, Leelakriangsak M, Zuber P (2003) A regulatory protein that interferes with activator-stimulated transcription in bacteria. Proc Natl Acad Sci U S A 100:4233-8. [PMID:12642660]
17. Core L, Perego M (2003) TPR-mediated interaction of RapC with ComA inhibits response regulator-DNA binding for competence development in Bacillus subtilis. Mol Microbiol 49:1509-22. [PMID:12950917]
PubMed search
Ortholog SSDB     COG
Paralog SSDB
Motif SSDB
Localization PSORT   SOSUI