BSTF Data for BG10100


ORF IDBG10100
SynonymabrB,cpsX
ClassHTH
Familyunique
Family descriptionparalog group(abh,abrB,spoVT)
Mutant/Isogenic strainJH12575/JH642(5)
Sensor
Target genesspo0E, abrB, aprE, spoVG(1), spo0H, kinC, ftsAZ, pbpE, tycA, rbs, argC, hutR(2), dppA(6), comK (9), sigW (10), sinIR (12), fadR (13)(repression). hpr (4) (activation)
cis SequenceWAWWTTTWCAAAAAAW(2), TGGNA(3), Flexibility in AbrB binding and recognition of three-dimensional DNA structures (7)
Ligandnot
CommentLooped-hinge helix fold for AbrB binding (8). AbrB negatively regulates biofilm formation (11).
Reference
1. Strauch MA (1995) In vitro binding affinity of the Bacillus subtilis AbrB protein to six different DNA target regions. J Bacteriol 177:4532-6. [PMID:7635837]
2. Strauch MA (1995) Delineation of AbrB-binding sites on the Bacillus subtilis spo0H, kinB, ftsAZ, and pbpE promoters and use of a derived homology to identify a previously unsuspected binding site in the bsuB1 methylase promote. J Bacteriol 177:6999-7002. [PMID:7592498]
3. Xu K, Strauch MA (1996) In vitro selection of optimal AbrB-binding sites: comparison to known in vivo sites indicates flexibility in AbrB binding and recognition of three-dimensional DNA structures. Mol Microbiol 19:145-58. [PMID:8821944]
4. Perego M, Hoch JA (1988) Sequence analysis and regulation of the hpr locus, a regulatory gene for protease production and sporulation in Bacillus subtilis. J Bacteriol 170:2560-7. [PMID:3131303]
5. Perego M, Hoch JA (1991) Negative regulation of Bacillus subtilis sporulation by the spo0E gene product. J Bacteriol 173:2514-20. [PMID:1901567]
6. Slack FJ, Mueller JP, Strauch MA, Mathiopoulos C, Sonenshein AL (1991) Transcriptional regulation of a Bacillus subtilis dipeptide transport operon. Mol Microbiol 5:1915-25. [PMID:1766371]
7. Xu K, Strauch MA (1996) In vitro selection of optimal AbrB-binding sites: comparison to known in vivo sites indicates flexibility in AbrB binding and recognition of three-dimensional DNA structures. Mol Microbiol 19:145-58. [PMID:8821944]
8. Vaughn JL, Feher V, Naylor S, Strauch MA, Cavanagh J (2000) Novel DNA binding domain and genetic regulation model of Bacillus subtilis transition state regulator abrB. Nat Struct Biol 7:1139-46. [PMID:11101897]
9. Hamoen LW, Kausche D, Marahiel MA, van Sinderen D, Venema G, Serror P (2003) The Bacillus subtilis transition state regulator AbrB binds to the -35 promoter region of comK. FEMS Microbiol Lett 218:299-304. [PMID:12586407]
10. Qian Q, Lee CY, Helmann JD, Strauch MA (2002) AbrB is a regulator of the sigma(W) regulon in Bacillus subtilis. FEMS Microbiol Lett 211:219-23. [PMID:12076816]
11. Hamon MA, Lazazzera BA (2001) The sporulation transcription factor Spo0A is required for biofilm development in Bacillus subtilis. Mol Microbiol 42:1199-209. [PMID:11886552]
12. Shafikhani SH, Mandic-Mulec I, Strauch MA, Smith I, Leighton T (2002) Postexponential regulation of sin operon expression in Bacillus subtilis. J Bacteriol 184:564-71. [PMID:11751836]
13. Gustafsson MC, von Wachenfeldt C (2001) A novel diffusible substance can overcome the apparent AbrB repression of the Bacillus subtilis fatR promoter. FEMS Microbiol Lett 199:197-202. [PMID:11377867]
PubMed search
Ortholog SSDB     COG
Paralog SSDB
Motif SSDB
Localization PSORT   SOSUI